We are small and flexible. Each of us is a plate spinner who juggles signal transduction, neural stem cells, cancer stem cells, multiple cell culture systems and disease models. We have elucidated novel molecular mechanisms that regulate brain stem cells and we work to improve our molecular understanding of this mechanism and do good with it in the context of a large number of diseases. Humor helps us cope.
Steven Poser, Ph.D
I became interested in signal transduction biology during my undergraduate studies. How cells integrate multiple signals from their environment became a central focus of my thesis work at the University of Washington, where I studied the regulation of coincidence intracellular pathways that controls mechanisms of proliferation, differentiation, survival and plasticity in the nervous system. I continued this work at the National Institutes of Health, helping to define the role of PI3-kinase, Notch, and JAK/STAT pathways in neural stem cell survival. I applied my expertise in multiple pharmaceutical industry settings through developing and executing primary cell-based assays that supported analgesia drug discovery programs, providing expertise in primary cell viability and function to support the development of novel transfection reagents for neurons and stem cells as well as managing programs to develop optimized presentation of stem cells in specific orthopedic applications. Most recently, I returned to academia to investigate the mechanisms for mobilizing endogenous stem cells populations in the treatment of degenerative conditions and the role of the STAT3-Serine/Hes3 signaling axis in the maintenance and proliferation of cancer stem cell populations.
I studied biology in Muenster and Bonn (Germany) with a focus on cell biology. I performed my diploma thesis in the department of Experimental Opthalmology of the University Hospital Bonn. I started my PhD thesis at the Max-Delbrueck Centre for Molecular Medicine in Berlin in the lab of Dr. Teymuras Kurzchalia, researching intracellular protein transport.
Then my life changed completely for a while: I gave birth to three children and took care of their health, happiness, and education (one of those years was in the U.S.A.) until the youngest entered school.
At that point I was very happy to join Dr. Kurzchalia's lab again, now at the Max Planck Institute of Molecular Cell Biology and Genetics, this time as a technician. There I successfully performed high throughput screens. Afterwards I joined the Innate Repair lab where I look after a wide range of tasks including cell culture, molecular biology, and various aspects of administration (financies, human resources, etc.).
As everybody knows: I am enjoying every single day in this lab. We are doing exciting research and we are FRIENDS!
Polyxeni Nikolakopoulou, MSc.
I studied Physics at the University of Athens, Greece. I continued my studies at the Technical University of Dresden, Germany, where I received my Masters Degree in Nanobiophysics. During my Masters I worked on the interface between Physics and Biology and decided to continue further in Neuroscience.
I started working in the Innate Repair lab in 2012, when I was introduced to the STAT3/Ser-Hes3 signaling axis. From then and on, I have worked with a variety of molecular, cellular, and translational models in order to elucidate the mechanisms controlling the plasticity of neural stem cells in the context of metabolic syndrome. My aim for the future is to keep working to understand what makes us who we are, our brain. Of course before that it would be good to get my PhD :)
Isabelle Nevado Alcalde
Laura Sebastian Monasor
Luis Alberto Rodriguez Cabrera
Carina Arps-Forker, Dipl.-Biol.
I am a Neuroscience student at the University of Nottingham. I have an interest in different aspects of brain biology. One of these is the endogenous regenerative ability of the brain and for this I have joined Innate Repair to learn concepts and techniques over the summer.