Steven Poser, Ph.D
I became interested in signal transduction biology during my undergraduate studies. How cells integrate multiple signals from their environment became a central focus of my thesis work at the University of Washington, where I studied the regulation of coincidence intracellular pathways that controls mechanisms of proliferation, differentiation, survival and plasticity in the nervous system. I continued this work at the National Institutes of Health, helping to define the role of PI3-kinase, Notch, and JAK/STAT pathways in neural stem cell survival. I applied my expertise in multiple pharmaceutical industry settings through developing and executing primary cell-based assays that supported analgesia drug discovery programs, providing expertise in primary cell viability and function to support the development of novel transfection reagents for neurons and stem cells as well as managing programs to develop optimized presentation of stem cells in specific orthopedic applications. Most recently, I returned to academia to investigate the mechanisms for mobilizing endogenous stem cells populations in the treatment of degenerative conditions and the role of the STAT3-Serine/Hes3 signaling axis in the maintenance and proliferation of cancer stem cell populations.